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This paper examines the effects of naturalistic psilocybin use outside of clinical research settings through a series of surveys. The study finds that psilocybin use is associated with lasting reductions in anxiety, depression, and alcohol misuse, as well as increased cognitive flexibility and well-being.

The classic psychedelic psilocybin, found in some mushroom species, has received renewed interest in clinical research, showing potential mental health benefits in preliminary trials.

This study explores why psychedelics help brain cells grow and change. It focuses on the 5-HT2A receptor, showing that specific parts of this receptor inside cells play a vital role in these positive effects.

This article aims to provide health care professionals with an overview of practical considerations for psilocybin therapy, such as pharmacology, dosing, administration, safety, and interactions. It aims to enhance healthcare professionals' knowledge and comfort in discussing and advising patients on psilocybin therapy to ensure better patient care and safety.

This review explores the potential of psychedelic-assisted therapy, using substances like ayahuasca, psilocybin, and LSD, as a promising alternative for treatment-resistant depression and anxiety. Based on the analysis of seven studies involving 130 patients, these psychedelics consistently demonstrated immediate and significant antidepressant and antianxiety effects with good safety profiles.

This paper discusses the growing scientific interest in psychedelics like psilocybin and LSD, exploring their potential for treating anxiety, depression, addiction, and inflammatory diseases through unique brain network mechanisms, suggesting a novel approach to therapy.

This paper explores the crucial role of the 5-HT2A receptor in the brain's cognitive function, focusing on its significance as the main target for psychedelics. The study delves into the receptor's response to different chemical classes and its association with hallucinogenic effects, drawing insights from human-based research.

This paper investigates the effects of psilocybin treatment on patients with treatment-resistant depression using functional MRI. It reveals changes in brain connectivity and blood flow that correlate with reduced depressive symptoms, suggesting a potential therapeutic mechanism.

This study examines the impact of psilocybin on depression and anxiety in cancer patients. Conducted as a randomized trial, the research reveals that high doses of psilocybin significantly reduce symptoms of depression and anxiety, leading to improved quality of life, well-being, and decreased death anxiety.

This comprehensive review takes a deep dive into the world of psychedelics, covering their historical use, safety profile, mechanisms of action, effects on perception, and potential therapeutic applications. The review offers a multifaceted exploration of psychedelics' intriguing history and promising future in the field of mental health.